Important FM summary paper in the Journal of the American Medical Association:
The Science of Fibromyalgia:
https://www.mayoclinicproceedings.org/article/S0025-6196(11)65223-3/pdf
fMRI shows distinct reactions to painful stimuli:https://www.ncbi.nlm.nih.gov/pubmed/27583567
Altered brain conductivity in FM:https://thejournalofheadacheandpain.springeropen.com/articles/10.1186/s10194-017-0799-x
People with FM have higher glutamate levels in the brain:https://www.ncbi.nlm.nih.gov/pubmed/18311814
People with fibromyalgia feel pressure as pain:https://www.ncbi.nlm.nih.gov/pubmed/12115241
CSF levels of 3 neurotransmitters (serotonin, norepinephrine, and tryptophan) were found to be lower in people with FM:https://onlinelibrary.wiley.com/doi/abs/10.1002/art.1780350509
MRI SPECT scans in people with fibromyalgia show decreased blood flow in the thalamus:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337836/
Strong genetic link in fibromyalgia:https://www.ncbi.nlm.nih.gov/pubmed/23280346
Non brain unique physical findings in people with fibromyalgia:
- Link between fibromyalgia and irritable bowel syndrome:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1754959/pdf/v063p00450.pdf
- Altered intestinal permeability in fibromyalgia: https://www.ncbi.nlm.nih.gov/pubmed/18540025
- Lower amount of intramuscular collagen in people with fibromyalgia:https://academic.oup.com/rheumatology/article/43/1/27/1778588
- Trans capillary permeability is reduced in fibromyalgia:https://www.ncbi.nlm.nih.gov/pubmed/7966078/
- During exercise muscle oxygen extraction was less in FM patients and the muscle recovery time (how long it took oxygen to normalize in the muscle) took significantly longer compared to people without fibromyalgia:https://www.medscape.com/viewarticle/804318?src=wnl_edit_tpal
City of Hope Research Studies:
- 2008 paper ****this study showed that guaifenesin has an effect on immune system proteins (chemokines and cytokine):http://www.fibromyalgiatreatment.com/uploads/2/6/5/7/26574962/city_of_hope_reprint.pdfAnd Dr. St. Amand’s interpretation of the study:http://www.fibromyalgiatreatment.com/uploads/2/6/5/7/26574962/dr_st_amands_explanation_of_city_of_hope_study.pdf
- 2010 paper:http://www.fibromyalgiatreatment.com/uploads/2/6/5/7/26574962/fms-plosone.pdf
- 2013 paper:http://www.fibromyalgiatreatment.com/uploads/2/6/5/7/26574962/fengetal2013.pdf
Presenting a donation for City of Hope Fibromyalgia Research:
